Topo-Geometric Filtration Scheme for Geometric Active Contours and Level Sets: Application to Cerebrovascular Segmentation

One of the main problems of the existing methods for the segmentation of cerebral vasculature is the appearance in the segmentation result of wrong topological artefacts such as the kissing vessels. In this paper, a new approach for the detection and correction of such errors is presented. The proposed technique combines robust topological information given by Persistent Homology with complementary geometrical information of the vascular tree. The method was evaluated on 20 images depicting cerebral arteries. Detection and correction success rates were 81.80% and 68.77%, respectively

Mapping the phase diagram of strongly interacting matter

We employ a conformal mapping to explore the thermodynamics of strongly interacting matter at finite values of the baryon chemical potential $\mu$. This method allows us to identify the singularity corresponding to the critical point of a second-order phase transition at finite $\mu$, given information only at $\mu=0$. The scheme is potentially useful for computing thermodynamic properties of strongly interacting hot and dense matter in lattice gauge theory. The technique is illustrated by an application to a chiral effective model.Comment: 5 pages, 3 figures; published versio

Extraction of Airways with Probabilistic State-space Models and Bayesian Smoothing

Segmenting tree structures is common in several image processing applications. In medical image analysis, reliable segmentations of airways, vessels, neurons and other tree structures can enable important clinical applications. We present a framework for tracking tree structures comprising of elongated branches using probabilistic state-space models and Bayesian smoothing. Unlike most existing methods that proceed with sequential tracking of branches, we present an exploratory method, that is less sensitive to local anomalies in the data due to acquisition noise and/or interfering structures. The evolution of individual branches is modelled using a process model and the observed data is incorporated into the update step of the Bayesian smoother using a measurement model that is based on a multi-scale blob detector. Bayesian smoothing is performed using the RTS (Rauch-Tung-Striebel) smoother, which provides Gaussian density estimates of branch states at each tracking step. We select likely branch seed points automatically based on the response of the blob detection and track from all such seed points using the RTS smoother. We use covariance of the marginal posterior density estimated for each branch to discriminate false positive and true positive branches. The method is evaluated on 3D chest CT scans to track airways. We show that the presented method results in additional branches compared to a baseline method based on region growing on probability images.Comment: 10 pages. Pre-print of the paper accepted at Workshop on Graphs in Biomedical Image Analysis. MICCAI 2017. Quebec Cit

Chiral phase transition in the presence of spinodal decomposition

The thermodynamics of a first order chiral phase transition is considered in the presence of spinodal phase separation within the Nambu-Jona-Lasinio (NJL) model. The properties of the basic thermodynamic observables in the coexistence phase are discussed for zero and non-zero quark masses. We focus on observables that probe the chiral phase transition. In particular, the behavior of the specific heat and entropy as well as charge fluctuations are calculated and analyzed. We show that the specific heat and charge susceptibilities diverge at the isothermal spinodal lines. We determine the scaling behavior and compute the critical exponent $\gamma$ of the net quark number susceptibility at the isothermal spinodal lines within the NJL model and the Ginsburg-Landau theory. We show that in the chiral limit the critical exponent $\gamma=1/2$ at the tricritical point as well as along the isothermal spinodal lines. On the other hand, for finite quark masses the critical exponent at the spinodal lines, $\gamma=1/2$, differs from that at the critical end point, $\gamma=2/3$, indicating a change in the universality class. These results are independent of the particular choice of the chiral Lagrangian and should be common for all mean field approaches.Comment: 12 pages, 11 figure

"Free" Constituent Quarks and Dilepton Production in Heavy Ion Collisions

An approach is suggested, invoking vitally the notion of constituent massive quarks (valons) which can survive and propagate rather than hadrons (except of pions) within the hot and dense matter formed below the chiral transition temperature in course of the heavy ion collisions at high energies. This approach is shown to be quite good for description of the experimentally observed excess in dilepton yield at masses 250 MeV < M < 700 MeV over the prompt resonance decay mechanism (CERES cocktail) predictions. In certain aspects, it looks to be even more successful, than the conventional approaches: it seems to match the data somewhat better at dilepton masses before the two-pion threshold and before the rho-meson peak as well as at higher dilepton masses (beyond the phi-meson one). The approach implies no specific assumptions on the equation of state (EOS) or peculiarities of phase transitions in the expanding nuclear matter.Comment: 13 pages, 3 PNG figures. submitted to Sov. Nucl. Phy

Thermal states of coldest and hottest neutron stars in soft X-ray transients

We calculate the thermal structure and quiescent thermal luminosity of accreting neutron stars (warmed by deep crustal heating in accreted matter) in soft X-ray transients (SXTs). We consider neutron stars with nucleon and hyperon cores and with accreted envelopes. It is assumed that an envelope has an outer helium layer (of variable depth) and deeper layers of heavier elements, either with iron or with much heavier nuclei (of atomic weight A > 100) on the top (Haensel & Zdunik 1990, 2003, astro-ph/0305220). The relation between the internal and surface stellar temperatures is obtained and fitted. The quiescent luminosity of the hottest (low-mass) and coldest (high-mass) neutron stars is calculated, together with the ranges of its possible variations due to variable thickness of the helium layer. The results are compared with observations of SXTs, particularly, containing the coldest (SAX J1808.4-3658) and the hottest (Aql X-1) neutron stars. The observations of SAX J1808.4-3658 in a quiescent state on March 24, 2001 (Campana et al. 2002, astro-ph/0206376) can be explained only if this SXT contains a massive neutron star with a nucleon/hyperon core; a hyperon core with a not too low fraction of electrons is preferable. Future observations may discriminate between the various models of hyperon/nucleon dense matter. The thermal emission of SAX J1808.4-3658 is also sensitive to the models of plasma ionization in the outermost surface layers and can serve for testing such models.Comment: 12 pages, 5 figures, 4 tables, LaTeX2e with aa.cls v.5.3 (included). Accepted by A&

Spin susceptibility of neutron matter at zero temperature

The Auxiliary Field Diffusion Monte Carlo method is applied to compute the spin susceptibility and the compressibility of neutron matter at zero temperature. Results are given for realistic interactions which include both a two-body potential of the Argonne type and the Urbana IX three-body potential. Simulations have been carried out for about 60 neutrons. We find an overall reduction of the spin susceptibilty by about a factor 3 with respect to the Pauli susceptibility for a wide range of densities. Results for the compressibility of neutron matter are also presented and compared with other available estimates obtained for semirealistic nucleon-nucleon interactions by using other techniques

Pionic contribution to relativistic Fermi Liquid parameters

We calculate pionic contribution to the relativistic Fermi Liquid parameters (RFLPs) using Chiral Effective Lagrangian. The RFLPs so determined are then used to calculate chemical potential, exchange and nuclear symmetry energies due to $\pi$$N$ interaction. We also evaluate two loop ring diagrams involving $\sigma$, $\omega$ and $\pi$ meson exchanges and compare results with what one obtains from the relativistic Fermi Liquid theory (RFLT).Comment: 6 pages, 2 figures, Published in Canadian Journal of Physics, vol. 88, issue 8, pp. 585-59

Long-term, Prolonged-release Tacrolimus-based Immunosuppression in De Novo Liver Transplant Recipients : 5-year Prospective Follow-up of Patients in the DIAMOND Study

Background. Immunosuppression with calcineurin inhibitors (CNIs) is reportedly associated with risk of renal impairment in liver transplant recipients. It is believed that this can be mitigated by decreasing initial exposure to CNIs or delaying CNI introduction until 3-4 d posttransplantation. The ADVAGRAF studied in combination with mycophenolate mofetil and basili ximab in liver transplantation (DIAMOND) trial evaluated different administration strategies for prolonged-release tacrolimus (PR-T). Methods. DIAMOND was a 24-wk, open-label, phase 3b trial in de novo liver transplant recipients randomized to: PR-T 0.2 mg/kg/d (Arm 1); PR-T 0.15-0.175 mg/kg/d plus basiliximab (Arm 2); or PR-T 0.2 mg/kg/d delayed until day 5 posttransplant plus basiliximab (Arm 3). In a 5-y follow-up, patients were maintained on an immunosuppressive regimen according to standard clinical practice (NCT02057484). Primary endpoint: graft survival (Kaplan-Meier analysis). Results. Follow-up study included 856 patients. Overall graft survival was 84.6% and 73.5% at 1 and 5 y post transplant, respectively. Five-year rates for Arms 1, 2, and 3 were 74.7%, 71.5%, and 74.5%, respectively. At 5 y, death-censored graft survival in the entire cohort was 74,7%. Overall graft survival in patients remaining on PR-T for z30 d was 79.1%. Graft survival in patients who remained on PR-T at 5 y was 87.3%. Patient survival was 86.6% at 1 y and 76.3% at 5 y, with survival rates similar in the 3 treatment arms at 5 y. Estimated glomerular filtration rate at the end of the 24-wk initial study and 5 y posttransplant was 62.1 and 61.5 mi./min/1.73 m(2), respectively, and was similar between the 3 treatment arms at 5 y. Overall, 18 (2.9%) patients had z1 adverse drug reaction, considered possibly related to PR-T in 6 patients. Conclusions. In the DIAMOND study patient cohort, renal function, graft survival, and patient survival were similar between treatment arms at 5 y posttransplant.Peer reviewe